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Chronic periodontitis is one of the most prevalent low-grade, bacterially induced, chronic inflammatory diseases affecting 20 to 50% of the adult population worldwide , .The low-grade inflammation associated with chronic periodontitis is characterized by increased levels of circulating pro-inflammatory cytokines (IL-1, IL-6, tumor necrosis factor α) and C-reactive protein , .From a pathophysiological point of view, inflammatory host mediators are involved in the detachment of the gingival connective tissue from the root surface, and in the resorption of alveolar bone supporting the tooth.The natural history of the disease leads to tooth loss.
the epithelial, connective and bone tissues that both surround and support the teeth .
To date, no study has specifically focused on the periodontal status of morbidly obese subjects (Body Mass Index ≥40 kg/m).
We hypothesized that periodontitis in morbidly obese subjects could alter the profile of inflammatory mediators.
All the examinations were completed by one periodontist (H.
R.), who was calibrated for probing to a “gold standard” senior clinical researcher (P. Examiner calibration was considered effective for an intraclass correlation coefficient ≥0.9.